Optimal Allocation of Sample Sizes to Multicenter Clinical Trials
نویسندگان
چکیده
منابع مشابه
Asymptotic Optimal Sample Sizes for Discovering a Promising Treatment in Phase II Group Sequential Clinical Trials
We propose an asymptotic optimal procedure for determining the per-study sample size of a series of Phase II clinical studies. The sequence of studies seeks to discover an active treatment among a sequence of treatments under evaluation. Each phase II study proceeds in r stages with r=1, 2, or 3. Our result serves two practical purposes. First, it yields asymptotic optimal sample sizes. Second,...
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ژورنال
عنوان ژورنال: Journal of Biopharmaceutical Statistics
سال: 2013
ISSN: 1054-3406,1520-5711
DOI: 10.1080/10543406.2013.789884